The Great Depression caused a reduction in the workforce to half previous, and a similar decrease in production.

[8] During World War II the main ANF plant at Blanc-Misseron initially produced orders for military use, and was later occupied by the German forces.

The plant was a target of Allied bombing in 1944 due to its use in keeping the rail network in occupied territory running.

[15] Following its takeover by Bombardier, the manufacturer has also signed contracts that provide for production at the Crespin site, including: a participation with Alstom in the construction of the MF 01, the so-called Autorail à grande capacité (AGC) trainsets, the Francilien NAT and Regio 2N trainsets.

On 4 December 2020, Bombardier Transportation announces a €25 million investment plan to modernise and increase the production capacity of its Crespin plant, in the presence of Xavier Bertrand, President of the Hauts-de-France region.