It follows the lives of veterinary surgeon Chris Brown at the Bondi Junction Veterinary Hospital[1][2][3] (near Bondi Beach), and emergency veterinarian Lisa Chimes at the Small Animal Specialist Hospital (SASH),[4] in the Sydney suburb of North Ryde.

[5] Also featured on Bondi Vet are Andrew Marchevsky, a specialist surgeon at SASH, and Tim Faulkner of the Australian Reptile Park at Somersby on the New South Wales central coast.

The series first broadcast on 5 February 2009, with the first two full seasons averaging a rating of 0.93 million viewers in the five capital cities.

[6] From 28 September 2013 to 25 May 2019, the show had been seen on Saturday mornings in the United States on Ten's sister network, CBS, under the title of Dr. Chris: Pet Vet, both as the Bondi community is unfamiliar to most American audiences, and to clarify Dr. Chris Brown as not the similarly named American musical artist.

[11] In February 2019, WTFN entertainment announced an additional two vets to the cast, with identical twin sisters Alison & Audrey Shen being included in the new series.