Boniface of Brussels (1183 – 19 February 1260) was a Catholic prelate who served as the Bishop of Lausanne from circa 1231 until 1239 when he resigned after agents of Holy Roman Emperor Frederick II assaulted him.

He was enthusiastic about this appointment but was faced with corrupt priests which he condemned in a pulpit address while also singling out King Frederick II.

[3] The king sent his agents to attack Boniface who sustained serious injuries but managed to escape.

In 1239, he travelled to Rome and secured permission from a reluctant Pope Gregory IX to resign.

[5] In 1245 he attended the First Council of Lyon which Pope Innocent IV had convoked, and later retired to La Cambre Abbey.