These solutions, which are colorless, are used for reductions and hydroboration, reactions that are useful in synthesis of organic compounds.

A common alternative to BHF•THF is borane–dimethylsulfide, which has a longer shelf life and effects similar transformations.

Alternatively, it can be prepared by the oxidation of sodium borohydride with iodine in THF.

[4] The following organoboron reagents are prepared from borane-THF: 9-borabicyclo[3.3.1]nonane, Alpine borane, diisopinocampheylborane.

[5] The solution is highly sensitive to air, requiring the use of air-free techniques.