As a major communications node for traffic between London and Portsmouth, Dover, south-east England generally and also travellers from Europe, Borough High Street had many coaching inns.

[6] Many of them dated back originally to the mediæval period, and were in use as coaching inns up to the mid-nineteenth century, when this mode of transport was superseded by the railway.

These inns were very famous and receive mention in the work of such literary giants as Chaucer, Shakespeare and Charles Dickens, though are now all gone - apart from the George.

[7] It is depicted by Anthony van den Wyngaerde's sixteenth century Panorama of London, which features Borough High Street prominently in the foreground of the picture.

[8] After demolition the site of the mansion and the area to the west of Borough High Street here became notorious as the criminal enclave of The Mint.

This means the numbering is now 4, 6 - 8, 10 actually accessed as a side stairway of 6-8 (gap stairs down to Cathedral and Borough Market) 14 (vault unit within the viaduct) 16 and (Southwark Street junction) 28.

Public Houses include: North to south - The Post Office (dated 1913) opposite Borough tube station closed in 2008.

The main Post Office at the northern end of the street originated as the Women's Ward of the 1852 development of St Thomas's Hospital.

David Bomberg House is a hall of residence[10][11] at 282–302 Borough High Street for London South Bank University students.

[14][15] The building is named after the English painter David Bomberg (1890–1957),[16] who was a teacher at London South Bank University when it was known as Borough Polytechnic.

[18] In 2009, a late night licence was granted for premises on the ground floor (Costcutter), despite a significant number of objections from residents.