In 1995, the school created the Liga Mayor program and participated in the Conferencia Nacional for the first time under head coach Santiago Caballero, finishing with a 1–7 record.

In 1997, now led by coach Rafael Garnica, Borregos Toluca finished 7–1 and won the Conferencia Nacional title after defeating the Guerreros Aztecas UNAM 35–22 in the championship game.

[6] In 2014, Borregos Toluca reached a championship game for the first time in its history, but lost against the Aztecas UDLAP 14–17.

[10] In June 2019, ITESM Toluca appointed former offensive coordinator Gustavo Tella as the team's new head coach.

[11] On 2 February 2022, authorities of ITESM Campus Toluca announced that the school's American football program for Liga Mayor would be disbanded.