Notable residents have included labor leader Walter P. Reuther, Rabbi Morris Adler, Detroit Tigers Harry Heilmann, Dizzy Trout, Michigan Supreme Court justices Franz C. Kuhn and Henry Butzel, U.S. Representative Vincent M. Brennan, Michigan governor Harry Kelly, boxer Joe Louis, druggist Sidney Barthwell, Congressman Charles C. Diggs Jr., Congressman George D. O'Brien, Motown record label founder Berry Gordy, Detroit Tiger Willie Horton, and dentist and pioneering WCHB radio station owner Wendell F.

[7] According to the 2000[8][9] Census data (which includes the surrounding streets of Atkinson, Clairmount, and Glynn Court) show Boston–Edison has both Black and White residents.

Voigt platted spacious lots and set building restrictions that established the unique character of the neighborhood.

[18] The subdivision included lots on West Boston, Chicago, Longfellow, and Edison, as well as on Atkinson to the south.

[6] These homes range in size from modest two-story vernaculars to massive mansions set on sprawling grounds.

In 1907, Ford had a brick and limestone Italian Renaissance Revival residence built at the corner of Edison and Second at a cost of $483,253.

[24] During the time that Ford lived in Boston–Edison, his introduction of the Model T, mass production methods, and wage-price theories revolutionized American industry.

[24] A historical marker issued by the State of Michigan, describing the history and significance of the home, is located on the front lawn.

(Two other Ford stockholders, John Dodge,[25] and Alexander Y. Malcomson,[26] lived in the adjoining Arden Park-East Boston neighborhood.)

[4] In addition, other pioneers in the early automobile industry such as Walter Briggs Sr. of Briggs Manufacturing Co,[4] four of the Fisher brothers (of Fisher Body),[7] Charles Lambert of Regal Motor Car Co., John W. Drake from Hupp Motor Car Co., and William E. Metzger from Cadillac and E-M-F.[4] likewise built homes in Boston–Edison.

[4] Additional notable early residents included conductor Ossip Gabrilowitsch and his wife Clara Clemens, Detroit Tigers owner Frank Navin, Detroit Tigers player Ty Cobb (who lived on nearby Atkinson Avenue at Third), historian Clarence M. Burton, and Rabbi Leo M.

In addition to the four Fisher brothers (a fifth brother, Frederic, lived in the adjacent Arden Park-East Boston neighborhood[25]), a number of Benjamin Siegel's relatives lived in the neighborhood, as did a number of Wagner family members (owners of Wagner's bakery).