[6] Augustana bassist Jared Palomar has stated that the song is loosely based on one of Layus' high school classmates who left to attend Duke University.

I must have been tapping into that when I was writing that song 'Boston' ...."[8] The music video for "Boston" was released on February 6, 2006, and was directed by Paul Fedor.

[10] "Boston" was used in the third-season finale of One Tree Hill, "The Show Must Go On", when Brooke Davis and Lucas Scott have their last dance as a couple.

Nathan and Haley drive away to their honeymoon meanwhile Lucas confesses to Peyton that he told Brooke about their kiss in the library.

American electronica project Owl City released a cover of the song on February 9, 2024, from the deluxe edition of his seventh studio album, Coco Moon.

He stated, "The song 'Boston' sort of starts in a 'classic' Owl City fashion, from what I can remember, with the cute synths modified to perfection and an overall bubbly feeling [...] We introduce distorted guitars, rebellious pop-punk vocals, and much more.