The Massachusetts Mental Health Center continues to operate at 75 Fenwood Road.

In November 1909 the site for the hospital was purchased on Fenwood Road, 5 minutes' walk from Harvard Medical School.

[2] Elmer Ernest Southard was appointed director of the hospital early in 1910, to supervise its construction.

[4][5] On May 1, 1919 the Massachusetts State Psychiatric Institute was separated from the Psychopathic Department of the Boston State Hospital, which relieved the psychopathic department of scientific research, leaving it with purely hospital functions.

[5] In 2009 the center's historic campus at 74 Fenwood Road was acquired by Partners HealthCare and demolished the following year.