[4] The U.S. Peace Corps returned to Botswana in August 2002 with a focus on HIV/AIDS-related programs after concluding 30 years of more broadly targeted assistance in 1997.

[5][6] Similarly, the USAID phased out a longstanding bilateral partnership with Botswana in 1996, after successful programs emphasizing education, training, entrepreneurship, environmental management, and reproductive health.

The United States International Board of Broadcasters (IBB) operates a major Voice of America (VOA) relay station in Botswana serving most of the African continent.

Botswana is one of the 15 focus countries for PEPFAR, the President's Emergency Plan for Aids Relief, and has received more than $556 million since the program began in January 2004 through September 2011.

[10] The Governments of Botswana and the United States entered into an agreement in July 2000 to establish an International Law Enforcement Academy (ILEA) in Gaborone.