Botswana sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7 to 18 September 2016.

[1] The country did not compete at the 2008 Summer Paralympics because its sole athlete Tshotlego Morama had an injury and the nation withdrew several hours before the 2012 Summer Paralympics because the Botswana National Olympic Committee cancelled its financial support due to financial irregularities.

[4] Botswana sent one athlete to the Rio Paralympic Games, sprinter Keatlaretse Mabote,[5] who was selected to be the flag bearer during the parade of nations in the opening ceremony.

[13][14][15] In an interview before the Paralympics, Mabote said he was positive about his chances despite the recent death of one of his siblings, "I want to be the first Motswana to bring the medal to this country and I have worked so hard for this.

[n 1][16] He was due to run in the men's 200 metres T12 on 16 September but withdrew because of a hamstring injury he sustained in Germany.