Box Office Poison is a series of comic books (originally published by Antarctic Press) by Alex Robinson.

The story concerns the life and trials of a group of young people in New York City.

Robinson stated that serializing such a long story in black-and-white form was inspired by Dave Sim's Cerebus.

[4] Box Office Poison features a wide array of major, supporting, and minor characters from many walks of life.

The French version of Box Office Poison, called De Mal En Pis, won the Prix Du Premier Album at the Angoulême International Comics Festival in 2005.