The women's middleweight boxing competition at the 2012 Olympic Games in London was held from 5 to 9 August at the ExCeL Exhibition Centre.

For the first time at an Olympic Games, the 10 men's boxing events were joined by three women's events: flyweight, lightweight and middleweight.

[1] Seventeen-year-old American Claressa Shields won gold in the women's middleweight, defeating Russia's veteran thirty-three-year-old Nadezda Torlopova by a score of 19–12 in the final.

[2] Her victory is depicted in the 2024 film The Fire Inside.

Bronze medals were awarded to both semi-final losers.