Bozhou (Chinese: 亳州; pinyin: Bózhōu) is a prefecture-level city in northwestern Anhui province, China.

It borders Huaibei to the northeast, Bengbu to the southeast, Huainan to the south, Fuyang to the southwest, and Henan to the north.

Its population was 4,996,844 at the 2020 census, of whom 1,537,231 lived in the built-up area made of Qiaocheng urban district, even though the county remains largely rural.

Rainfall is heavily concentrated in the warmer months, as more than half of the annual total occurs from June to August.

The city is located on two main Chinese train routes running from capital Beijing to the south and from the east to Shanghai which facilitate the easy transportation of goods and people.