It is named after Greenlandic Arctic researcher Jørgen Brønlund, or after the namesake fjord on which it is located.
Brønlundhus was built in 1947–48 by the Danish Peary Land Expeditions on initiative of Eigil Knuth, through an air lift by PBY Catalina seaplanes from Zackenbergbasen, a station built for that purpose close to a trapper's hut at the site of present Zackenberg research station area 1000 km farther south.
Brønlundhus was used as a base for the first expedition 1948–50 when Peary Land was explored by scientists on dog sled.
In 1972 a new station, Kap Harald Moltke, was built at Cape Harald Moltke, some ten kilometers east of Brønlundhus, on the opposite side of Jørgen Brønlund Fjord, where an old raised seabed provides a natural runway, making air access possible.
In 2001, a Nanok team found the station in reasonably good condition, and performed minor repairs and exterior maintenance with paint and felt.