Selected late in the tenth round of the 1992 NFL draft, he became a consistent starter for the Minnesota Vikings, Tampa Bay Buccaneers, and Chicago Bears.
[5][7] While Culpepper was a Florida undergraduate, he was also an active member of Sigma Chi Fraternity (Gamma Theta Chapter).
[14] In his nine-year professional career, Culpepper played in 131 games, started 83 of them,[1] and recorded 34 quarterback sacks and one safety.
[17] Prior to his appearances, Culpepper's wife Monica was selected as a participant for the 24th season of the CBS reality television show Survivor.
[21] On February 8, 2017, Culpepper was revealed to be one of the contestants competing in Survivor: Game Changers, the show's 34th season, which began airing in March 2017.
However, at his endgame, he won five individual immunity challenges; a feat shared only by a few other elite Survivor players, which propelled him to the Final Three with Sarah Lacina and "Troyzan" Robertson.
Although Culpepper played a solid social game and was a prominent threat, he became very arrogant and made some remarks toward fellow tribe mate Tai Trang that other players perceived as condescending in the last few days.
Fellow tribemate Aubry Bracco in her jury speaks video controversially said she had hesitations about voting for Brad to win because of his "racist and sexist tendencies".
At the Final Tribal Council, Lacina's skillful strategic and social gameplay was preferred by the jury over Culpepper's physical dominance, and she was awarded the title of "Sole Survivor" in a 7–3–0 vote.