He is best known for co-creating the television series Glee, American Horror Story, Scream Queens, and Pose with Ryan Murphy.

[2][4] Falchuk's career in television began as a writer for Mutant X (2001), Earth: Final Conflict (2001–02) and Veritas: The Quest (2003), before he was hired to work on the first season of Nip/Tuck in 2003.

[2] As Nip/Tuck neared its sixth and final season, Falchuk and Murphy began to look for their next project, and decided to focus on a lighter subject.

They teamed up with Ian Brennan, who had written a screenplay about high school show choirs, to pitch a one-hour comedy about a glee club to the Fox Broadcasting Company.

[citation needed] In 2011, Falchuk co-created the FX horror-drama anthology series American Horror Story with previous collaborator Ryan Murphy.

[6] Falchuk is an executive producer on American Crime Story with Ryan Murphy, which began airing on February 2, 2016.

[7] Falchuk, Murphy and Brennan also created Fox's horror comedy series Scream Queens, which ran from September 2015 to December 2016,[8] and starred Emma Roberts, Lea Michele, Abigail Breslin, Keke Palmer and Jamie Lee Curtis.

After undergoing emergency spinal surgery, he made a full recovery, and his experience inspired parts of the Glee episode "Wheels".