[6][7] He is also the former chairman of IG Acquisition Corp.[8] Tusk is a columnist for Fast Company,[9] and is the author of The Fixer: My Adventures Saving Startups from Death by Politics.

[10] He previously served as the campaign manager for New York City Mayor Michael Bloomberg's successful 2009 re-election bid, as Deputy Governor of Illinois, as Communications Director for US Senator Chuck Schumer[11] and as an early political advisor to Uber.

[16] After graduating from college, Tusk became the spokesperson for the New York City Parks Department and helped run various divisions of the agency, most notably launching a successful campaign to change the way New Yorkers obey the leash law.

[28] Combining his backgrounds in finance and politics, Tusk developed a successful framework to help states monetize their lotteries.

[29] In 2015, Tusk ran a public affairs campaign for Uber that included television, radio, and digital ads as well as direct mail and grassroots organizing in opposition to a cap on rideshare vehicles proposed by New York City Mayor Bill de Blasio.

[30] The campaign argued that "the company was good for the city, providing jobs and transportation for less affluent residents in the outer boroughs".

[41] Tusk Venture Partners has worked with over three dozen startups including Bird, FanDuel, Lemonade, Handy, Eaze, Nexar, GlamSquad, Ripple, MainStreet, Nurx, Ro, Kodiak Robotics, pymetrics, Grove and Care/Of, solving a variety of political, regulatory and media challenges solely in return for equity in each company and for investment rights in each company's next round of financing.

[42][43] Tusk Venture Partners 1 raised its first fund in 2016 and began deploying capital into startups including Lemonade,[44] Nexar, Care/Of, Circle, Coinbase, Bird, Ro and FanDuel.

[45][46] Ivory Gaming Group was co-founded by Bradley Tusk and Christian Goode in 2015 to reopen the Chukchansi Gold Resort & Casino.

[51] In 2017, Tusk Philanthropies launched an initiative to popularize the need for mobile voting to citizens and elected officials across the country.

[54] In 2018, Tusk wrote The Fixer: My Adventures Saving Startups from Death by Politics (published by Penguin Group).