Commonly as a frequent enemy of the Doom Patrol and the Teen Titans, he is a French genius and criminal mastermind.

[1] The Brain appears as the main antagonist in the third season of the HBO Max series Doom Patrol, voiced by Riley Shanahan.

His colleague Niles Caulder grows jealous of his work and arranges for the Brain to get caught in an explosion, which destroys his body.

[4] The Brain and Mallah form the Brotherhood of Evil in hopes of conquering the world and getting revenge on Caulder where it gains members like Madame Rouge, General Immortus, and Garguax.

The Brotherhood go against the newly formed Justice League, with the Brain using a genetic splicer to take the Flash's legs, Green Lantern's ring, Black Canary's vocal chords, and Martian Manhunter's eyes.

[14][15] In the Dawn of DC series Unstoppable Doom Patrol, Mallah betrays and kills Brain while the two are fighting General Immortus.