The Math edition is the only version available outside Japan, and was released on April 5, 2009, in North America and June 19, 2009, in the PAL regions, as a launch title for the service.

However, the Arts & Letters edition was released on August 10, 2009, in North America and October 23, 2009, in the PAL regions.

One puzzle in each of these two editions utilizes the Nintendo DSi's camera function, while both versions allow players to use a photo for their in-game profile.

On June 19, 2015, Brain Age Express: Sudoku was pulled from the DSi Shop and 3DS eShop, with no official reason given.

Like their predecessors, both versions feature modes called "Brain Age Check" and "Training".

For Brain Age Check, it uses Stroop Test, Connect Maze, Rock, Paper, Scissors, Word Memory, and Symbol Match.

[7] The Training mode features puzzles from previous games, these are Reading Aloud, Word Scramble and Piano Player.

The two Brain Age Express titles were announced on October 2, 2008, at the reveal of the Nintendo DSi and its DSiWare service[4] and were released on December 24, 2008.

During the subcommittee, members from a variety of teams came together to come up with small titles that could be downloaded from the Internet as part of a "My DS" brand.

The meetings' progress was considerably slow, due to the nature of the Nintendo DSi being undetermined at that point.

Several rough ideas were presented, but none stood out, and as a result, possible projects piled up, creating a bad situation.

The developers wondered how much content could be included for this game to still be considered a Chotto title, as no particular size, standard, or guidelines had been set.

Kawashima gave him his assent, stating that a difference between players' brain ages may arise, and would help them determine whether they are more math- or art-oriented.

The Brain Age Express titles were a part of the "My DS" theme, which allows players to customize their Nintendo DSis, resulting in people naturally thinking that there would be only one save slot.

[12] A photo comparison game in the Arts and Letters version was described as simple yet difficult by Takahashi and Kawamoto.

Of what they've played, Nintendo has given it the polish that titles in a series that's sold more than ten million copies should, also complimenting them for feeling like full games despite the limited content.