Due to great success at the Spanish box office, the film spawned off a sequel, Brain Drain 2 (2011).

The film begins with an 18 year old Emilio (Mario Casas) who credits his amorous misadventures with Natalia (Amaia Salamanca) to his physical problems (orthodoncy, orthosis, etc.)

However, once there, the group must confront several problems, such as their poor English and their disabilities and quirks (one of Emilio's friends is blind, another is paraplegic and the last one is a drug dealer).

In its first week at the Spanish theaters, the film reached €1.22 mill at the office box and nearly 200,000 spectators saw it.

With those takings, Brain Drain was the first on the Spanish box and a hit forward to State of Play.