Brandon Barlow (born January 25, 1998) is an American professional football defensive lineman for the Hamilton Tiger-Cats of the Canadian Football League (CFL).

[2] On August 3, 2022, it was announced that Barlow had signed with the Toronto Argonauts.

[2] In his next game, on August 26, 2022, also against the Tiger-Cats, he recorded his first sack when he tackled Dane Evans late in the fourth quarter.

[5] Barlow made his first start in the last game of the regular season on October 29, 2022, against the Montreal Alouettes where he had three defensive tackles.

[2] Barlow became a free agent upon the expiry of his contract on February 13, 2024.