London led UMass in receptions (50) and receiving yards (781) during his senior year (2006).

A day after being waived by the Giants, London was claimed off waivers by the Miami Dolphins on August 31, 2008.

After a lackluster performance in the 2009 NFL preseason, London was waived by the Miami Dolphins on September 5, 2009.

Brandon London signed with the Montreal Alouettes of the Canadian Football League near the close of the 2010 CFL season.

In the 2011 season London played in all 18 games and scored his first CFL touchdown on September 11, 2011.