[4] Brandywine is in the southernmost area of Prince George’s County, surrounded by a rural setting.

The CDP and town are adjacent to the southern border of Prince George's County, lying east and west of busy Maryland Route 5/U.S.

Brandywine CDP is bordered by Accokeek to the west, Clinton and Rosaryville to the north, Croom to the northeast, and Cedarville to the southeast, all in Prince George's County.

The Brandywine zip code area encompasses parts of both counties and includes Cedarville and Baden.

William H. Early named the town of Brandywine as property he owned in the mid-19th century.

[12][13] Although located between the substantial bedroom cities of Clinton and Waldorf, Brandywine remained rural until after the turn of the twenty-first century, when shopping centers—including big-box stores—and small residential developments were built.

Despite the building of both a major highway overpass and a roundabout in 2019, the community is still notorious for traffic slowdowns due to both daily local commuters and interstate travelers.

identified by the Maryland-National Capital Park and Planning Commission, none of which are currently museums:[14][failed verification][15][failed verification] The Brandywine community includes Gwynn Park High School, several well-known automobile salvage lots, a construction equipment vehicle sales lot, and a large furniture warehouse.

[17] The community's new Southern Area Aquatics and Recreational Complex offers services to residents of all ages.