The first known permanent settlement of the area of today's Bratislava was the Linear Pottery Culture, around 5000 BC in the Neolithic era.

Around 200 BC, the Celtic Boii tribe established an oppidum on the site of today's Bratislava Castle.

Bratislava Regio was abolished in 1928 and replaced by a new territorial unit called the "Slovak Land".

During the WWII Slovak Republic, Bratislava county was restored, albeit with somewhat modified borders.

[7] The economy of the Bratislava Region accounts for about a quarter(EUR 20 billion) of the Slovak GDP.

[9] Important branches include chemical, automobile, machine, electrotechnical and food industries.

The 2009 regional elections were won by Pavol Frešo (SDKÚ–DS) over the independent candidate Vladimír Bajan.