Bilateral relations between the countries have recently increased, as a result of Brazil's new South–South foreign policy aimed to strengthen South American integration.

During a state visit by Brazilian President Luiz Inácio Lula da Silva to Georgetown on 2 March 2007, the governments of Guyana and Brazil signed several cooperation agreements and announced plans to boost trade between the two countries.

[citation needed] On 26 August 1968 Deputy Prime Minister Ptolemy Reid visited Brazil for discussions with leaders of the Brazilian government.

[3] In November 2002, it was reported that Brazil had carried out a military operation in the region of Guyana claimed by Suriname, to destroy several airstrips used by drug traffickers.

[5][failed verification] The Brazil–Guyana Joint Commission for Infrastructure Development was created in 2017 during President David Granger's visit to Brazil.