Although not considered as big as Argentina's rivalries with Brazil or Uruguay, the games between them have a very tense atmosphere due to their infamous encounter in the de facto final of the 1950 FIFA World Cup where Uruguay completely shocked the Brazilian favorites 2–1 at the Maracanã Stadium in Brazil, allowing La Celeste to claim their 2nd World Cup title.

However, Brazil would suffer another embarrassing defeat at home soil: this time, against Germany, when they lost 7–1, at the Mineirão in the 2014 FIFA World Cup semi-finals.

[7] At the 1920 South American Championship, A Seleção recorded their biggest ever defeat to any country, when they conceded 6 goals to La Celeste on 18 September 1920 at the Estadio Valparaíso Sporting Club in Viña del Mar, Chile.

On the contrary, Uruguay were preparing for an upset and captain, Obdulio Varela, told his teammates, while they were in his bathroom to spit and urinate on a bunch of Brazilian newspapers that had already declared Brazil, winners of the tournament.

The entire stadium (except the Uruguayan players) was eerily quiet for some moments, returning to support Brazil for the rest of the game.

However, after the final whistle, the crowd fell back into deep silence and sadness, and many Brazilians were heartbroken after the match and there was no celebration in the streets.

[24] Pelé, also produced one of the most memorable plays in football history, when in the second half, he played a through pass from Tostão, and fooled Uruguay keeper, Ladislao Mazurkiewicz, by not touching the ball, causing the keeper to come out of his penalty area and allowing Pele to make a clear shot.

[29] In the second leg, Carlos Aguilera scored the equaliser which secured a win of the tie 3–1 on both points and aggregate to ensure Uruguay's 12th Copa América title.

In the 49th minute, Romário scored the only goal of the game, to ensure Brazil's victory and avenge the team that lost at the same stadium back in 1950.

[31] During qualification for the 1994 FIFA World Cup, Brazil and Uruguay were drawn in the same group together along with Bolivia, Ecuador, and Venezuela, during which the top two would qualify for the tournament in a double round-robin format.

In the 72nd minute, Romário soared and headed a powerful ball to break the dreadlock and score his first goal for the national team in 5 years after being exiled for disciplinary issues, despite being one of the best footballers in the world at the time.

Ten minutes later, Romário scored again; this time running past keeper Robert Siboldi to tap it home and seal a 2–0 win.

[37] On 1 July 2001, Brazil played against Uruguay in a notable FIFA World Cup qualifier at the Estadio Centenario in Montevideo.

However, Uruguayan goalkeeper, Fabián Carini, appeared to be holding the ball in his own net, but referee Hugh Dallas did not think it was an equalizer.

[40] Uruguay would go on to be knocked out in the group stage, while Brazil would win the entire competition, when Ronaldo scored 2 goals in the final against Germany.

Two minutes later, Gilberto Silva attempted to clear the ball away with his head, but it went right over the goalkeeper, giving Uruguay a 3–2 lead in Brazil.

Uruguay opened the scoring after Javier Delgado's free kick into the box reached Marcelo Sosa, who sent it to the back of the net with a diving header.

In the shoot-out, Uruguayan player Vicente Sánchez's shot was saved by Júlio César which would prove decisive in Brazil winning 5–3 on penalties and progressing to the final.

In the 13th minute of the game, Brazilian defender David Luiz pulled Diego Lugano in the box and the referee awared Uruguay a penalty, which Júlio César) saved from Forlán.

Near the end of the game, Paulinho scored a last-minute winner for Brazil to make it 2–1 and send them through to their third consecutive Confederations Cup final.

Uruguay came into the tournament in great form, while Brazil was dealing with injuries to key players such as Neymar and Richarlison and going through an identity crisis.