Brenda M. Greene (born 1950) is an American scholar, author, literary activist, and radio host at Medgar Evers College of the City University of New York.

She is the former board chair of the Nkiru Center for Education and Culture, co-founded by hip hop icons Yasiin Bey and Talib Kweli.

Powered by this mission, Greene has forged long-standing friendships and collaborations with many supportive individuals, including Sonia Sanchez, Susan Taylor, Danny Glover, Michael Eric Dyson, Marita Golden, Edwidge Danticat, Khalil Gibran Muhammad, Tracy K. Smith, Colson Whitehead, a host of elected officials throughout New York, and many others.

Similarly, her strategic partnerships with institutions such as the Schomburg Center for Research in Black Culture, Bedford Stuyvesant Restoration Corporation, Amazon Literary Partnership, New-York Historical Society, African Voices, the Brooklyn Literary Council, the College of Education at Sacramento State, and others, have resulted in progressive programs and initiatives throughout the decades.

Her guests have included Elizabeth Alexander, Tracy K. Smith, Walter Mosley, David Dinkins, Ta-Nehisi Coates, Edwidge Danticat, Michael Eric Dyson, Cornel West, Haki R. Madhubuti, Amiri Baraka, Ishmael Reed, and Tananarive Due among others.