In 2024, she unsuccessfully ran for the U.S. House of Representatives in Maryland's 6th congressional district, losing to former state delegate Neil Parrott in the Republican primary election.

[3] Thiam graduated from Hoke County High School in 1987, and later attended North Carolina Central University in 1994, earning a Bachelor of Science degree in physical education.

[2] After graduating from North Carolina Central University, Thiam worked as a special-education teacher for Washington County Public Schools[4] and for various nonprofits until 2019,[2] While working for the Washington County Public Schools, she secured a $100,000 grant to support the ongoing education of teachers for students with intellectual disabilities.

[14] The Washington County Republican Central Committee nominated Thiam to fill the vacancy later that month,[5] and she was appointed to the seat by Governor Larry Hogan on September 23, 2020.

[25] Thiam was defeated in the Republican primary election by former state delegate Neil Parrott on May 14, 2024, placing second-to-last with 3.3 percent of the vote.

[28] She also described herself as "pro-life", expressing interest in working with legislators to promote family planning options other than abortions,[29] and said she opposed the "defund the police" movement.

[34] In February 2021, during debate on a bill to extend the earned-income tax credit to immigrants, Thiam introduced an amendment that required that benefits only go to "taxpayers of lawful status in the United States".

[36] The letters were later withdrawn by their authors, House Minority Leader Jason C. Buckel and state senator George C. Edwards, following criticism from local officials and some constituents.

[50] During her 2024 congressional campaign, Thiam said that she supported restarting construction on the Mexico–United States border wall and opposed mask and vaccine mandates imposed during the COVID-19 pandemic.

[51] She also said that she disagreed with Judge Deborah Boardman's ruling against requiring the Montgomery County Public Schools system to provide parents with the ability to opt their students out of classroom instruction on LGBTQ topics,[52] and opposed removing Donald Trump from the 2024 presidential election ballot under the Fourteenth Amendment, saying that she did not believe that the January 6 U.S. Capitol attack was an insurrection.

[53] In October 2023, amid the 2023 Hamas-led attack on Israel and subsequent Israel–Hamas war, Thiam expressed support for Israel and its right to defend itself, as well as the expansion of the Abraham Accords and humanitarian efforts in Gaza;[54] however, she later said that she opposed giving foreign aid to any country without first addressing domestic issues and implementing limits on how much aid could be given and for how long.