[1] After stints with the Toronto Maple Leafs, Vegas Golden Knights, Vancouver Canucks and Los Angeles Kings, he was signed by the Washington Capitals to a one-year, $700,000 contract on July 1, 2019.

[10] In the 2012–13 season with the Portland Winterhawks, Leipsic scored 120 points in 68 games to win the CHL Top Scorer Award as the highest-scoring player in the Canadian Hockey League.

On February 15, 2015, the Predators traded Leipsic along with Olli Jokinen and Nashville's 2015 first round draft pick to the Toronto Maple Leafs in a package deal for Cody Franson and Mike Santorelli.

[13] Leipsic played an important role down the stretch in helping the Toronto Marlies (a team that struggled to score early in the year) reach the post-season.

[14] Leipsic made his debut the same night, in a road game against the Vancouver Canucks, and scored his first NHL goal midway through the second period, batting a flying puck out of mid-air and past goaltender Ryan Miller.

Leipsic opted to resume his career by agreeing to a one-year contract with the Russian club, HC CSKA Moscow of the KHL, on August 4, 2020.

On May 7, 2021, Leipsic was traded by CSKA to Metallurg Magnitogorsk in exchange for the rights to Lias Andersson, and immediately signed a two-year contract with the club.

[22] On June 23, 2023, Leipsic continued his tenure in the KHL by signing as a free agent to a two-year contract with perennially contending club, SKA Saint Petersburg.

Leipsic tenure with SKA ending after a lone season and on May 31, 2024, he was signed to a two-year contract with his fourth KHL club, Avtomobilist Yekaterinburg.