Brenner Children's Hospital has its own Emergency Department, including the first Level I Pediatric Trauma Care unit in North Carolina.

Brenner Children's Hospital generally treats children from western North Carolina, as well as parts of Virginia, South Carolina and Tennessee, although some come from further away for advanced care.

It initially began when the family financed the Brenner Center for Adolescent Medicine in 1981, which was focused on developing a teaching program in adolescent medicine for students and pediatric residents, as well as a clinic at what was then North Carolina Baptist Hospital.

In April 2002, Brenner Children's opened the $132 million Ardmore Tower West.

In addition to its 144 private rooms, Brenner Children's has six playrooms, an interactive video wall and a rooftop garden with playground equipment.