[4] Anderson began writing and drawing his own comics on school binder paper, creating a pantheon of his own that included "Radium the Robot" and "The Chameleon".

[7] The X-Men: God Loves, Man Kills graphic novel followed,[8] as well as artwork on a number of Marvel Comics series, including the heroic space-opera Strikeforce: Morituri.

Other work included J. Michael Straczynski's Rising Stars: Untouchable spin-off series written by Fiona Avery covering the life story of special assassin Laurel Darkhaven.

[14] In April 2022, Anderson was reported among the more than three dozen comics creators who contributed to Operation USA's benefit anthology book, Comics for Ukraine: Sunflower Seeds, a project spearheaded by IDW Publishing Special Projects Editor Scott Dunbier, whose profits would be donated to relief efforts for Ukrainian refugees resulting from the February 2022 Russian invasion of Ukraine.

"My greatest joy in drawing comics comes when I've added nuance to a character with just the right expression and illustrated a scene that captures the perfect moment of mood.