[6] On January 17, 2007, the Pirates traded Lillibridge with Mike Gonzalez to the Atlanta Braves for Adam LaRoche and Jamie Romak.

On July 12, 2008, in a game against the San Diego Padres at Petco Park, Lillibridge hit his first major league home run against relief pitcher Joe Thatcher.

[9] On December 4, 2008, the Braves traded Lillibridge, Tyler Flowers, Jon Gilmore, and Santos Rodriguez to the Chicago White Sox for Javier Vázquez and Boone Logan.

[11] Lillibridge garnered media coverage after he made two back-to-back, game-saving and game-ending defensive catches while playing right field on April 26, 2011.

[12] On June 24, 2012, Lillibridge was traded to the Boston Red Sox with Zach Stewart for Kevin Youkilis and cash.

Lillibridge was traded by Boston to the Cleveland Indians on July 24, for minor league pitcher José De La Torre.

[20] On April 19, Lillibridge cleared waivers, and was assigned to the Triple-A Iowa Cubs of the Pacific Coast League.

[30] As of December 2024, Lillibridge is the owner of BASE by Pros, a batting cage and baseball and softball training facility in the suburbs of Seattle, Washington.