The Ursuline Superior General, Mother Clare Gaukler, bought a piece of land at 1285 Western Road in London, and construction began on a permanent building in 1923.

The building was built by contractor Joseph Michael Piggot, opened for classes and residence in 1925, and was named Brescia Hall.

Brescia was known as a liberal arts school and the courses taught were: English, French, Spanish, Philosophy, History, Classics, and Religious Knowledge.

The Honours Bachelor of Science in Foods and Nutrition at Brescia was accredited by Dietitians of Canada, making graduates eligible to apply for dietetic internship placements.

Brescia offered a Master of Foods and Nutritional Sciences program, divided into two streams: The internship MSc stream, available to those who graduated from a programme accredited by Dietitians of Canada, combining a master's degree with an internship and graduates could write the exam needed to become a registered dietitian.

Ursuline Hall was Brescia's original building and residence, but housed classrooms, food laboratories and administrative offices before the schools closure.

In September 2013, Brescia opened its new residence building and dining pavilion, Clare Hall, which continues to operate, housing just over 300 students and includes an eatery called the Mercato.