The earliest indications of the beer-brewery legacy in this neighborhood can be seen on maps from the 1860s, which list several minor German brewers and distillation facilities in this region.

With the collapse of local industry later in the 20th century, originally started by the implementation of Prohibition in the United States, and later beer production moving primarily to the Midwest, no brewer was operating in that neighborhood by 1987.

During this late 20th-century slump, the entirety of North Philadelphia, Brewerytown included, was hit hard by economic depressions.

Bus Routes 7, 48, and 49 also serve the area, traveling along North 29th Street between the Strawberry Mansion and Fairmount neighborhoods and crossing the Benjamin Franklin Parkway to and from Center City Residents are in the School District of Philadelphia.

Three K-8 schools include portions of the historic district : Edward Gideon, William Kelley, and Robert Morris.