On September 8, 2006, Burres made his major league debut with the Orioles, allowing two earned runs on three hits in two-thirds of an inning against the New York Yankees.

[5] Burres was named the fifth starter in the Orioles rotation to open the 2008 season, after a competition in spring training with teammate Matt Albers.

[9] Jays' manager Cito Gaston stated that Burres would remain in the rotation until several of Toronto's injured pitchers make their return to active duty.

On January 4, 2010, Burres signed a minor league contract with the Pittsburgh Pirates that included an invitation to spring training.

On October 31, Burres was removed from the 40-man roster and sent outright to the Triple-A Indianapolis Indians, but he rejected the assignment and elected free agency.

[13] On January 18, 2012, Burres returned to his original team, the San Francisco Giants, signing a minor league contract that included an invite to spring training.

[14] In 22 starts split between the rookie-level Arizona League Giants and Triple-A Fresno Grizzlies, he accumulated a 4-6 record and 5.13 ERA with 73 strikeouts across 105+1⁄3 innings pitched.

On February 4, 2013, after little interest from MLB and NPB teams, Burres signed with the Lamigo Monkeys of the Chinese Professional Baseball League.

On January 11, 2023, Burres was hired by the San Diego Padres to serve as an assistant coach for their High-A affiliate, the Fort Wayne TinCaps.

Brian competes every year in the prestigious “Battle for the Boot” golf tournament held at Bandon Dunes and has won four times (2012, 2016, 2022, 2023).