Brian De Keersmaecker (born 6 May 2000) is a Belgian professional footballer who plays as a midfielder for Dutch club Heracles Almelo.

De Keersmaecker made his professional debut with Beerschot in a Europa League Playoff 2–0 win over K.A.S.

[2] He was sent on a one-season loan to Dutch second-tier Eerste Divisie club FC Eindhoven on 5 October 2020.

[3] In May 2021 Beerschot decided not to renew his contract, making him a free agent in July.

[5] In June 2023, De Keersmaecker signed for Heracles Almelo on a four-year contract.