Brian Alan Holzinger (born October 10, 1972) is an American former professional ice hockey center.

He played in the National Hockey League with the Buffalo Sabres, Tampa Bay Lightning, Pittsburgh Penguins and the Columbus Blue Jackets.

He made his National Hockey League debut with the Sabres during the 1994–95 season, appearing in four regular season games and four playoff games (scoring two goals during the Sabres' playoff series against the Philadelphia Flyers).

A broken leg suffered just prior to the 2002–03 season ensured Holzinger was again on the sidelines for the first half of the year.

As a result of this trade, Holzinger was the third Ohio native to play for the Blue Jackets franchise.