[2] Krzanich has served on the Deere & Co. and Semiconductor Industry Association boards, as well as the Drone Advisory Committee, which advises the Federal Aviation Administration.

[16][17] Intel worked to use conflict-free minerals for all microprocessors by 2014 and all products by 2016, and Krzanich was included in the documentary film Merci Congo (2016).

[7][10][22] In this role, Krzanich has been credited for expanding Intel's offerings beyond central processing units (CPUs) and into other technologies, including 5G wireless networks, artificial intelligence, autonomous vehicles,[23][24] cloud computing, drones, and wearables.

[31][32][33] In addition to Intel's Diversity in Technology initiative, the company's Hack Harassment campaign has worked to address cyberbullying with Krzanich as CEO.

[42][43][44] In August, Krzanich became the third executive to leave the Trump administration's American Manufacturing Council in 24 hours (following Kenneth Frazier and Kevin Plank, the CEOs of Merck & Co. and Under Armour, respectively), based on the president's response to the Unite the Right rally.

[53][54] According to various news outlets, the extramarital affair began before the enactment of the anti-fraternization policy and ended several years before the investigation and his subsequent resignation.

[57][58][59][60] On November 7, 2018, Krzanich was announced to be the new chief executive officer and president of CDK Global, replacing former CEO Brian MacDonald.

[61] In July of 2022, Krzanich stepped down from the position and Brian P. MacDonald was appointed acting President and Chief Executive Officer.

[citation needed] In June 2016, Krzanich canceled an event at his home that was reported by The New York Times to be a fundraiser in support of then-nominee Donald Trump.