Magee turned professional in March 1999, and fought Dean Ashton at the Bowler's Arena, Manchester, England on the undercard of a bill that included Damaen Kelly, Michael Brodie and Clinton Woods.

In December 2008 he beat undefeated Scottish Stevie Maguire to win the British super middleweight title,[3] and, after a 13-month break, returned to defeat Mads Larsen in a seven-round knockout in Aarhus, becoming European champion for the first time.

On 11 September 2010 Brian Magee defended his European Title against Armenia's Roman Aramian with the Armenian not starting the ninth round.

On 30 July 2011 Magee captured the interim WBA super-middleweight title with a unanimous points win over Jaime Barboza in San Jose, Costa Rica.

Brian Magee travelled to Denmark to face "The Viking Warrior" Mikkel Kessler in his home nation with the WBA Super Middleweight Title at stake.