Brian James O'Keefe (born July 15, 1993) is an American professional baseball catcher in the Kansas City Royals organization.

[3] O'Keefe made his professional debut with the Low-A State College Spikes, batting .239 with three home runs and 17 RBIs in 47 games.

He split the 2015 season between State College and the Single-A Peoria Chiefs, accumulating a .241/.311/.397 slash in 47 games.

In 2016, O'Keefe played for Peoria and the High-A Palm Beach Cardinals, clubbing 13 home runs and 64 RBI to go along with a .252/.361/.436 triple slash.

O'Keefe split the 2017 campaign between Peoria, Palm Beach, and the Double-A Springfield Cardinals, hitting .262/.320/.433 with a career-high 15 home runs and 48 RBI in 101 games between the three affiliates.

[6] He spent the 2021 campaign split between the Double-A Arkansas Travelers and the Triple-A Tacoma Rainiers, logging a slash of .269/.349/.485 while posting career-highs in home runs (24) and RBI (70) in 105 combined games.

[7] On December 3, 2021, O'Keefe re-signed with the Mariners organization on a minor league contract and received an invitation to Spring Training.