When he played the full match in Denmark's 4–1 win over England on 17 August 2005, Priske aroused the interest of several Premiership clubs, and he joined Portsmouth five days later for an undisclosed fee, signing a three-year deal.
Many Portsmouth supporters assumed that this was because of Redknapp's disdain of using players he himself had not purchased, and speculation was rife in the January transfer window that Priske would be leaving the club.
A move away from Fratton Park never materialized, however, and following Portsmouth's poor run of form and injuries to several defenders, Priske was returned to the side for match against Manchester City on 11 March.
Priske was from then an ever-present as Portsmouth then went on an excellent run of form for their final ten matches of the season, earning the club Premiership survival for another year.
Many were originally unhappy that Priske had been frozen-out of the team with Redknapp's return, and felt justified in their valuation of the player after the impressive role he played in earning the club survival from relegation.
Priske had become a fan favourite since his arrival at Fratton Park as a result of his impressive form, but in spite of this, rumours of his departure from the south coast resurfaced during the 2006–07 pre-season.
[10] On 14 December 2023, Priske and AC Sparta Prague qualified for the knockout stages of the UEFA Europa League after beating Aris Limassol 3–1 and finishing second in a group also featuring Real Betis and Rangers.
In October 2024, Feyenoord won away games against Girona and Benfica in the Champions League and beat Twente, Go Ahead Eagles and Utrecht in the Eredivisie, before losing De Klassieker to Ajax.
In the remainder of 2024, Feyenoord won five of their seven games in the Eredivisie and came back from 3–0 down to draw 3–3 against Manchester City and beat Priske's former club Sparta Prague in the Champions League.
After Feyenoord started 2025 with a defeat against Utrecht and a draw against Willem II, there were rumours Priske would leave the club after the home game against Bayern Munich in the Champions League.
[19] In the following weeks, Feyenoord suffered their largest-ever Champions League defeat against Lille (6–1), lost away to Ajax in the Eredivisie and were knocked out in the KNVB Cup quarter-finals by PSV Eindhoven.