Brienno (Comasco: Brienn [briˈɛn]) is a comune (municipality) in the Province of Como in the Italian region of Lombardy, located about 50 kilometres (31 mi) north of Milan and about 10 kilometres (6 mi) northeast of Como.

Brienno borders the following municipalities: Argegno, Carate Urio, Laglio, Nesso, and Schignano.

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