After the ascension to the throne of Charles Albert of Sardinia on 27 April 1831 a major reform of the military of the Kingdom of Piedmont was undertaken.

The brigade participated in the First Italian War of Independence fighting in the battles of Santa Lucia, Goito and Novara.

After the entry of Italy into the war on 20 June 1940 the division entered France in the area of Argentera.

The division saw heavy combat near Himarë and Vuno when the Greek army managed to break through the Italian lines after the Battle of Himara.

After Italy's surrender to the Allies on 3 September 1943 the divisions commanding general Antonio Gandin was left without clear orders from his superiors.

In 1991 after the end of the Cold War the Italian Army disbanded a large number of its mechanized units in Northern Italy and transferred their equipment to the Acqui: consequently the brigade's infantry battalions received VCC-2 armoured personnel carriers, while the 48th "Taro" was equipped with M109L self-propelled howitzers.

Before the brigade was disbanded on 30 June 1996 its units were either disbanded or joined other brigades: in 1995 the 17th Infantry Regiment "Acqui" (Recruits Training) and the 123rd Infantry Regiment "Chieti" (Recruits Training) joined the Army Training Command, while the 130th Mechanized Infantry Battalion "Perugia", Logistic Battalion "Acqui", and the 48th Self-propelled Field Artillery Regiment "Taro", which had been renamed 33rd Self-propelled Field Artillery Regiment "Acqui" on 11 September 1995, joined the Mechanized Brigade "Granatieri di Sardegna" on 15 May 1996.

In 2002 the Italian Army raised three division commands, with one of the three always readily deployable for NATO missions.