Dr. Samuel A. Levine introduced the arm-chair treatment of myocardial infarction in the 1950s and his protégé Dr. Bernard Lown was an early innovator in the development of the coronary care unit in the 1960s.

[4] In April 2017, Brigham and Women's announced they would be offering voluntary buyouts to 1,600 staff in an effort to control costs.

The hospital was profitable, but this move was due to higher labor and other costs amid stagnant payments from insurance companies.

[5] Also in April 2017, the United States District Court for the District of Massachusetts announced that Brigham and Women's Hospital and its nonprofit hospital and physicians network, Partners HealthCare, agreed to pay a $10 million fine to resolve allegations that a stem cell research lab fraudulently obtained federal grant funding.

[10] In 2019, BWH opened the Brigham Preventive Genomics Clinic,[11] becoming one of the first hospitals in the United States[12] to offer DNA sequencing, reporting, and interpretation of disease-associated genes to healthy patients seeking to reduce their risk of future disease.