Brislington Brook runs through the area in the woodlands of Nightingale Valley and St Anne's Wood.

Brislington formerly housed the HTV West Studios on Bath Road, and this is situated next to the historic Arnos Vale Cemetery.

[3] Brislington is also near to the site of the now demolished chapel of St. Anne's-in-the Wood (actually in nearby St Anne's), erected by one of the Lords de la Warr, whose family held the manor of Brislington from the late 12th to the mid-16th century; in the 15th century the chapel was a place of pilgrimage, visited by Henry VII.

After the chapel was demolished following the Dissolution of the Monasteries, Thomas Amory built a house called "St. Ann's" at the site in the mid-17th century.

[5][6][7] The Palladian fronted building was originally seven separate blocks into which patients were allocated depending on their class.

The buildings, estate and therapeutic regime designed by Edward Long Fox was based on the principles of moral treatment which was fashionable at the time.

In the early 21st century, Brislington's paint works was converted to studios, offices and houses, home to arts and media organisations.