On March 17, 1976, Brittany and her twin sister, Cynthia, were born in Gainesville, Florida, to Carolyn and Charlton Bradford "C.B."

In 1992, when she was sixteen, Brittany won the role of Mila Rosnovsky on the short-lived syndicated teen drama Swan's Crossing.

During the run of Sweet Valley High, they made their film debut in the drama The Basketball Diaries (1995) alongside Leonardo DiCaprio.

Daniel appeared on the show It's Always Sunny in Philadelphia as a transgender woman named Carmen.

[4] That same year, she appeared in the VH1 television movie Totally Awesome before landing a lead role in The CW's half-hour comedy The Game, which she starred in until 2011.

In March 2014, Daniel revealed her reason for her departure from The Game in 2011, was due to her being diagnosed with Stage 4 Hodgkin lymphoma, for which she underwent chemotherapy.