It is located on the southern slope of the Horka hill and its surroundings consist mainly of the forested area of ​​the Soběšice uplands, which are used for tourism and recreation by the locals.

The 1940 publication Vranov u Brna lists older Paleolithic finds from Ořešín; later a stone axe head, probably Neolithic, was found here.

However, the Zábrdovice convent was in debt and in 1327 sold Ořešín to the Cistercian nuns of Staré Brno, who used funds donated by their founder, Queen Eliška Rejčka, for this transaction.

The nuns owned this property until the monastery was abolished in 1782; Ořešín was administered as part of their Cacovice estate.

The number of houses in the village remained the same for many decades, and only began to increase in the last quarter of the 18th century thanks to the serfdom and land reform, which was carried out in 1784, including the rabization and the definitive abolition and division of the meierhof.

[8] After the abolition of the Cistercian monastery, the Staré Brno estate, including Ořešín, was administered by the state religious fund from 1782.

The estate was purchased in 1825 by the Staré Brno lawyer Franz Heintl, from whose sons it was acquired in 1843 by Eduard, Prince of Schönburg-Hartenstein, who held it for several years until the abolition of the patrimonial administration.

The estate was inherited by the descendants of Prince Eduard, so it remained in the possession of the Schönburg-Hartenstein family until 1945, when it was expropriated based on the Beneš decrees.

It was also planned to be extended from the upper part of the village through the forest to Útěchov, which was first postponed and then cancelled before World War I, as such an investment would have required Ořešín to go into heavy debt.

By 1911, the local businesses registered included an inn, tobacco and liquor sales, and three shops.

[15][18] During the turn of the 19th and 20th centuries, the composition of the population gradually changed; in 1924, only two farmers lived here, while the number of housekeepers, who mainly worked as workers in industrial plants in the area increased.

[15] During World War II, two residents of Ořešín were killed as political prisoners in German concentration camps.

In the post-war period, the communists also had a political advantage in Ořešín, but the national socialists retained the position of chairman of the local committee, even after February 1948.

[21] On 17 October 1949, a new bus line from Řečkovice via Mokrá Hora and Jehnice to Ořešín began operating.

[23] The small pond in the village square was replaced in 1950 with a concrete fire tank, abolished shortly after 2000.

[24][25] Due to the low number of farmers, which had been decreasing over a long period of time due to the small area of ​​the fields, a unified agricultural cooperative was not established here as part of the collectivization of agriculture, but local farmers were forced to join the Jehnice state farm in 1957.

[30] When Brno was reorganized after the fall of communism, the city district of Brno-Ořešín was established on 24 November 1990.

[38][39][40][41] After the switch from communism to capitalism, Ořešín avoided a greater degree of suburbanization, and its development was not as fast as in other suburbs of Brno.

[43] Ořešín lies on the southern and southwestern slope of the unforested Horka hill, on the western edge of the prominent forested ridge of the Drahany highlands, facing south towards Brno.

Ořešín was exclusively Czech-speaking for a long time, the number of German speakers was zero even until 1945, with the sole exception of 1930, when there was one German-speaking resident registered.

[54] Since Ořešín has retained its village appearance, supplemented by a smaller amount of newer suburban construction, there are no larger establishments here.

[57] On the southern edge of the city district is the collection yard of the municipal enterprise SAKO Brno, which deals with waste management.

[61] The nearest railway stations are Brno-Řečkovice and Česká, located on the Brno-Havlíčkův Brod line, 3 kilometers from Ořešín.

[62] In 1872, a one-class school was built in Jehnice on the village square, which was also intended for pupils from Ořešín and Mokrá Hora.

[62] In 2011, a container school building was built on Drozdí street in Ořešín itself,[36][37] which houses the charitable organization Mateřská škola Oříšek Brno, founded by Brno-Ořešín.