The railway past the site of Broadmeadows station originally opened in 1872, as part of the North East line to School House Lane.

[7] The station was initially provided with a 150-foot (46 m)-long platform, a goods siding and shed, and a passing loop for trains on the single track.

[8] The level crossing at Camp Road was initially protected by hand-operated gates, with boom barriers provided in 1961.

[9] Barry Road also had a level crossing, which was replaced by the current overpass in 1957,[10] as part of the construction of the standard gauge line.

[12] In 1889, a lever frame in the signal box was installed, and was replaced in 1929, when the Albion-Jacana freight line opened.

The original 1878 station building was demolished in 1988,[13] and was replaced by a new structure, which was opened on 16 March 1990 by then Transport Minister Jim Kennan, as part of a commercial development of the site.

[18][19] During World War II, an Army siding was provided to Broadstore, located to the north-east of the station.

The Broadstore branch was a single un-electrified track, extending in an easterly direction for approximately 1.6 kilometres and terminating at the Maygar Barracks on Camp Road.

[24] The goods service had been detaching a number of livestock wagons and was given clearance to enter the Albion–Jacana freight line.

[28][29] On 3 February 2003, an unattended Comeng set, led by carriage 394M, rolled away from Broadmeadows station, and ran as far as Spencer Street, where it collided with V/Line locomotive N463, which was leading a Bacchus Marsh-bound train.