A top prospect with the Waterloo Black Hawks of the United States Hockey League (USHL), Boeser was selected 23rd overall in the 2015 NHL entry draft by the Canucks and spent the following two seasons with the University of North Dakota.

[14] On January 10, 2018, Boeser was named to his first career NHL All-Star Game as a member of the Pacific Division roster.

[20] Despite missing the final 16 games of the 2017–18 season, Boeser was named a finalist for the Calder Memorial Trophy, which is awarded to the league's best rookie of the year.

After missing two games in November due to his groin injury, Boeser was sent back to Vancouver to be examined by a specialist, while the team was on a road trip.

[28] On October 11, 2023, Boeser scored four goals and recorded his first NHL career natural hat trick in the season-opening game against the Edmonton Oilers.

[32] His first International Ice Hockey Federation (IIHF)-sanctioned tournament was the 2016 World Junior Championships, where he had three points in seven games as the United States won the bronze medal.

[34] Boeser's father was diagnosed with Parkinson's disease in 2010; he would also have a severe brain injury from a car accident a few years later, forcing him to stop working.

To help support the family Boeser's mother worked up to three jobs, including serving in a restaurant, office administration, and preparing tax returns.

[35] In August 2014, while Boeser was in Slovakia for the Ivan Hlinka Memorial Tournament, a tragic car accident south of Minneapolis–St.

Paul killed one of his closest friends and severely injured another, both fellow students and athletes at Burnsville High School.